Susceptibility locus for Alzheimer's disease on chromosome 10

被引：305

作者：

Myers, A

Holmans, P

Marshall, H

Kwon, J

Meyer, D

Ramic, D

Shears, S

Booth, J

DeVrieze, FW

Crook, R

Hamshere, M

Abraham, R

Tunstall, N

Rice, F

Carty, S

Lillystone, S

Kehoe, P

Rudrasingham, V

Jones, L

Lovestone, S

Perez-Tur, J

Williams, J

Owen, MJ

Hardy, J

Goate, AM

机构：

[1] Washington Univ, Sch Med, Dept Psychiat, St Louis, MO 63110 USA

[2] Mayo Clin Jacksonville, Neurogenet Lab, Jacksonville, FL 32224 USA

[3] Univ Wales Coll Med, Dept Psychol Med, Cardiff CF4 4XN, S Glam, Wales

[4] Inst Psychiat, London SE5 8AF, England

[5] CSIC, Inst Biomed Valencia, Unitat Genet Mol, E-46010 Valencia, Spain

来源：

SCIENCE | 2000年 / 290卷 / 5500期

关键词：

D O I：

10.1126/science.290.5500.2304

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The apolipoprotein E (APOE) gene is the only genetic risk factor that has so far been Linked to risk for Late-onset Alzheimer's disease (LOAD), However, 50 percent of Alzheimer's disease cases do not carry an APOE4 allele, suggesting that other risk factors must exist. We performed a two-stage genome-wide screen in sibling pairs with LOAD to detect other susceptibility Loci. Here we report evidence for an Alzheimer's disease Locus on chromosome 10. Our stage one multipoint Lod score (Logarithm of the odds ratio for linkage/no Linkage) of 2.48 (266 sibling pairs) increased to 3.83 in stage 2 (429 sibling pairs) close to D10S1225 (79 centimorgans). This Locus modifies risk for Alzheimer's disease independent of APOE genotype.

引用

页码：2304 / +

页数：3

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