When ubiquitin meets ubiquitin receptors: a signalling connection

被引：242

作者：

Di Fiore, PP

Polo, S

Hofmann, K

机构：

[1] Istituto Europeo di Oncologia, 20141, Milan

[2] Ist. FIRC di Oncologia Molecolare, 20139, Milan

[3] University of Milan, 20122, Milan

[4] MEMOREC Stoffel GmbH, D50829 Koeln

来源：

NATURE REVIEWS MOLECULAR CELL BIOLOGY | 2003年 / 4卷 / 06期

关键词：

D O I：

10.1038/nrm1124

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Ubiquitylation is emerging as a versatile device for controlling cellular functions. Here, we propose that monoubiquitylation is rapidly induced by signalling events and allows the establishment of protein-protein interactions between monoubiquitylated proteins and partners that contain distinct ubiquitin-binding domains. We also put forward speculative models for the regulation of monoubiquitylation versus polyubiquitylation.

引用

收藏

页码：491 / 497

页数：7

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