Structure of fuscopeptins, phytotoxic metabolites of Pseudomonas fuscovaginae

被引：45

作者：

Ballio, A

Bossa, F

Camoni, L

DiGiorgio, D

Flamand, MC

Maraite, H

Nitti, G

Pucci, P

Scaloni, A

机构：

[1] UNIV ROMA LA SAPIENZA, CNR, CTR MOLEC BIOL, I-00185 ROME, ITALY

[2] UNIV CATHOLIQUE LOUVAIN, UNITE PHYTOPATHOL, B-1348 LOUVAIN, BELGIUM

[3] UNIV NAPLES FEDERICO II, CNR, SERV SPETTROMETRIA MASSA, I-80134 NAPLES, ITALY

来源：

FEBS LETTERS | 1996年 / 381卷 / 03期

关键词：

fuscopeptins; lipodepsipeptides; phytotoxins; Pseudomonas fuscovaginae;

D O I：

10.1016/0014-5793(96)00043-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the fuscopeptins, bioactive lipodepsipeptides produced in culture by the gramineae pathogen Pseudomonas fuscovaginae, has been determined, The combined use of FAB mass spectrometry, NMR spectroscopy and chemical and enzymatic procedures allowed one to define a peptide moiety corresponding to ZDhb-DPro-LLeu-DAla-DAla-DAla-DAla-DVal- Gly-DAla-DVal-DAla-DVal-ZDhb-DaThr-LAla-LDab-DDab-LPhe with the terminal carboxyl group closing a macrocyclic ring on the hydroxyl group of the allothreonine residue. The N-terminus is in turn acylated by 3-hydroxyoctanoate in fuscopeptin A and 3-hydroxydecanoate in fuscopeptin B. Some preliminary data on the biological activity of fuscopeptins are also reported.

引用

页码：213 / 216

页数：4

共 19 条

[1] SYRINGOPEPTINS, NEW PHYTOTOXIC LIPODEPSIPEPTIDES OF PSEUDOMONAS-SYRINGAE PV SYRINGAE [J].