Crosstalk of reactive oxygen species and NF-κB signaling

被引：2088

作者：

Morgan, Michael J. ^{[1
]}

Liu, Zheng-gang ^{[1
]}

机构：

[1] NCI, Cell & Canc Biol Branch, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

来源：

CELL RESEARCH | 2011年 / 21卷 / 01期

基金：

美国国家卫生研究院;

关键词：

reactive oxygen species (ROS); NF-kappa B; oxidative stress; antioxidants; TUMOR-NECROSIS-FACTOR; MANGANESE SUPEROXIDE-DISMUTASE; DNA-BINDING ACTIVITY; HYDROGEN-PEROXIDE FORMATION; TERMINAL KINASE ACTIVATION; EARLY EMBRYONIC LETHALITY; PROTEIN-TYROSINE KINASE; ALPHA-INDUCED APOPTOSIS; NITRIC-OXIDE SYNTHASE; INDUCED CELL-DEATH;

D O I：

10.1038/cr.2010.178

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

NF-kappa B proteins are a family of transcription factors that are of central importance in inflammation and immunity. NF-kappa B also plays important roles in other processes, including development, cell growth and survival, and proliferation, and is involved in many pathological conditions. Reactive Oxygen Species (ROS) are created by a variety of cellular processes as part of cellular signaling events. While certain NF-kappa B-regulated genes play a major role in regulating the amount of ROS in the cell, ROS have various inhibitory or stimulatory roles in NF-kappa B signaling. Here we review the regulation of ROS levels by NF-kappa B targets and various ways in which ROS have been proposed to impact NF-kappa B signaling pathways.

引用

页码：103 / 115

页数：13

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