A common class of nematode glutathione S-transferase (GST) revealed by the theoretical proteome of the model organism Caenorhabditis elegans

被引：27

作者：

Campbell, AM ^{[1
]}

Teesdale-Spittle, PH ^{[1
]}

Barrett, J ^{[1
]}

Liebau, E ^{[1
]}

Jefferies, JR ^{[1
]}

Brophy, PM ^{[1
]}

机构：

[1] Aberystwyth Univ, Inst Biol Sci, Aberystwyth SY23 3DA, Dyfed, Wales

来源：

COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY | 2001年 / 128卷 / 04期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Glutathione S-transferase; nematode; Heligmosomoides polygyrus; homology modelling; detoxification; Caenorhabditis elegans; proteome; genome verified;

D O I：

10.1016/S1096-4959(00)00360-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The genome verified C. elegans free-living nematode model is a new tool for investigating gene expression in human and animal nematode parasites. There is limited information on designating glutathione S-transferase (GST) to specific classes in lower invertebrates such as nematodes. Following cloning, amino acid sequence alignment, recombinant expression and Western blotting we provide evidence of a new GST class in nematodes or lower invertebrates. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：701 / 708

页数：8

共 25 条

[1] The genome sequence of Drosophila melanogaster
Adams, MD
Celniker, SE
Holt, RA
Evans, CA
Gocayne, JD
Amanatides, PG
Scherer, SE
Li, PW
Hoskins, RA
Galle, RF
George, RA
Lewis, SE
Richards, S
Ashburner, M
Henderson, SN
Sutton, GG
Wortman, JR
Yandell, MD
Zhang, Q
Chen, LX
Brandon, RC
Rogers, YHC
Blazej, RG
Champe, M
Pfeiffer, BD
Wan, KH
Doyle, C
Baxter, EG
Helt, G
Nelson, CR
Miklos, GLG
Abril, JF
Agbayani, A
An, HJ
Andrews-Pfannkoch, C
Baldwin, D
Ballew, RM
Basu, A
Baxendale, J
Bayraktaroglu, L
Beasley, EM
Beeson, KY
Benos, PV
Berman, BP
Bhandari, D
Bolshakov, S
Borkova, D
Botchan, MR
Bouck, J
Brokstein, P
[J]. SCIENCE, 2000, 287 (5461) : 2185 - 2195
[2] Board PG, 1997, BIOCHEM J, V328, P929
[3] BOARD PG, 2000, IN PRESS CHEM BIOL I
[4] GLUTATHIONE S-TRANSFERASES FROM THE GASTROINTESTINAL NEMATODE HELIGMOSOMOIDES-POLYGYRUS AND MAMMALIAN LIVER COMPARED
BROPHY, PM
BENSMITH, A
BROWN, A
BEHNKE, JM
PRITCHARD, DI
[J]. COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY B-BIOCHEMISTRY & MOLECULAR BIOLOGY, 1994, 109 (04): : 585 - 592
[5] GLUTATHIONE-S-TRANSFERASE (GST) EXPRESSION IN THE HUMAN HOOKWORM NECATOR-AMERICANUS - POTENTIAL ROLES FOR EXCRETORY-SECRETORY FORMS OF GST
BROPHY, PM
PATTERSON, LH
BROWN, A
PRITCHARD, DI
[J]. ACTA TROPICA, 1995, 59 (03) : 259 - 263
[6] PARASITIC HELMINTH GLUTATHIONE S-TRANSFERASES - AN UPDATE ON THEIR POTENTIAL AS TARGETS FOR IMMUNOTHERAPY AND CHEMOTHERAPY
BROPHY, PM
PRITCHARD, DI
[J]. EXPERIMENTAL PARASITOLOGY, 1994, 79 (01) : 89 - 96
[7] Genome sequence of the nematode C-elegans:: A platform for investigating biology
不详
[J]. SCIENCE, 1998, 282 (5396) : 2012 - 2018
[8] Plant glutathione S-transferases:: enzymes with multiple functions in sickness and in health
Edwards, R
Dixon, DP
Walbot, V
[J]. TRENDS IN PLANT SCIENCE, 2000, 5 (05) : 193 - 198
[9] SWISS-MODEL and the Swiss-PdbViewer: An environment for comparative protein modeling
Guex, N
Peitsch, MC
[J]. ELECTROPHORESIS, 1997, 18 (15) : 2714 - 2723
[10] HABIG WH, 1974, J BIOL CHEM, V249, P7130

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