Gene expression profile of normal lungs predicts genetic predisposition to lung cancer in mice

被引：8

作者：

Gariboldi, M

Spinola, M

Milani, S

Pignatiello, C

Kadota, K

Bono, H

Hayashizaki, Y

Dragani, TA ^{[1
]}

Okazaki, Y

机构：

[1] RIKEN, Lab Genome Explorat Res Grp, Yokohama, Kanagawa, Japan

[2] Ist Nazl Tumori, Dept Expt Oncol, I-20133 Milan, Italy

[3] Univ Tokyo, Tokyo, Japan

[4] Univ Milan, Inst Med Stat & Biometry, Milan, Italy

来源：

CARCINOGENESIS | 2003年 / 24卷 / 11期

关键词：

D O I：

10.1093/carcin/bgg133

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Genetic susceptibility to lung tumorigenesis shows large variations among mouse strains. To test whether genetic predisposition to lung tumorigenesis is associated with a specific gene expression profile in normal lungs, we analyzed gene expression in 16 inbred strains of known susceptibility/resistance to lung tumorigenesis, using the RIKEN mouse full-length cDNA 19K microarray set. The strain-specific expression profile of 91 cDNA clones correlated with strain lung tumor susceptibility/resistance and predicted, by principal component analysis, the genetic predisposition to lung tumorigenesis in mice.

引用

页码：1819 / 1826

页数：8

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