Too much short chain fatty acids cause neonatal necrotizing enterocolitis

被引:60
作者
Lin, J [1 ]
机构
[1] CUNY Mt Sinai Sch Med, Jack & Lucy Clark Dept Pediat, Div Newborn Med, New York, NY 10029 USA
关键词
D O I
10.1016/S0306-9877(03)00333-5
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Nenatal necrotizing enterocolitis (NEC) is a disease mainly affects premature infants. It is well known that prematurity, enteral formula feeding, and bacterial. colonization are three major risk factors for NEC. Acetic acid, propionic acid and butyric acid are short chain fatty acids (SCFAs), which are produced mainly in the colon by bacterial. fermentation of undigested carbohydrates. Although luminal production of modest quantities of SCFAs is essential for normal colonic mucosal function, excessive production/ accumulation of SCFAs may arise in premature infants due to increased luminal carbohydrates malabsorption and poor gastrointestinal motility, and may have deleterious effects on mucosal integrity. Therefore, it is proposed that too much luminal short chain fatty acids cause neonatal NEC. (C) 2003 Elsevier Ltd. All rights reserved.
引用
收藏
页码:291 / 293
页数:3
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