New insights into insulin resistance in the diabetic heart

被引：107

作者：

Gray, Susan ^{[1
]}

Kim, Jason K. ^{[1
,2
]}

机构：

[1] Univ Massachusetts, Sch Med, Program Mol Med, Worcester, MA 01605 USA

[2] Univ Massachusetts, Sch Med, Dept Med, Div Endocrinol Metab & Diabet, Worcester, MA 01605 USA

来源：

TRENDS IN ENDOCRINOLOGY AND METABOLISM | 2011年 / 22卷 / 10期

基金：

美国国家卫生研究院;

关键词：

ACTIVATED PROTEIN-KINASE; STRESS SIGNALING PATHWAY; ACETYL-COA CARBOXYLASE; FATTY-ACID OXIDATION; DIET-INDUCED OBESITY; SKELETAL-MUSCLE; CARDIAC DYSFUNCTION; GLUCOSE-TRANSPORT; ADIPOSE-TISSUE; MITOCHONDRIAL DYSFUNCTION;

D O I：

10.1016/j.tem.2011.05.001

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Insulin resistance is a major characteristic of obesity and type 2 diabetes, and develops in multiple organs, including the heart. Compared with its role in other organs, the physiological role of insulin resistance in the heart is not well understood. The heart uses lipid as a primary fuel, but glucose becomes an important source of energy in ischemia. The impaired ability to utilize glucose might contribute to cell death and abnormal function in the diabetic heart. Recent discoveries regarding the role of inflammation, mitochondrial dysfunction and endoplasmic reticulum (ER) stress in obesity have advanced our understanding of how insulin resistance develops in peripheral organs. In this review, we examine these findings in relation to the diabetic heart to provide new insights into the mechanism of cardiac insulin resistance.

引用

页码：394 / 403

页数：10

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