Pharmacokinetic studies on 5-aminolevulinic acid-induced protoporphyrin IX accumulation in tumours and normal tissues

被引:55
作者
Heyerdahl, H
Wang, I
Liu, DL
Berg, R
AnderssonEngels, S
Peng, Q
Moan, J
Svanberg, S
Svanberg, K
机构
[1] INST CANC RES,DEPT BIOPHYS,N-0310 OSLO,NORWAY
[2] UNIV LUND HOSP,MED LASER CTR,S-22185 LUND,SWEDEN
[3] UNIV LUND HOSP,DEPT ONCOL,S-22185 LUND,SWEDEN
[4] LUND UNIV,DEPT PHYS,S-22100 LUND,SWEDEN
[5] NORWEGIAN RADIUM HOSP,DEPT PATHOL,N-0310 OSLO,NORWAY
关键词
laser-induced fluorescence; fluorescence diagnostics; fluorescence microscopy; basal cell carcinoma; 5-aminolevulinic acid (ALA); protoporphyrin IX build-up;
D O I
10.1016/S0304-3835(96)04576-4
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Laser-induced fluorescence (LIF) for in vivo point monitoring and fluorescence microscopy incorporating a CCD camera were used to study the fluorescence distribution of 5-aminolevulinic acid (ALA)-induced protoporphyrin IX (PpIX) in tumours. Fluorescence in a chemically induced adenocarcinoma in the liver of rats and in an aggressive basal cell carcinoma in a patient were studied after intravenous injection of ALA at a dose of 30 mg/kg body weight. The LIF technique demonstrated slightly more ALA-induced PpIX fluorescence in the tumour than in the surrounding normal liver and abdominal muscle of rats. The visible parts of the human basal cell carcinoma exhibited strong ALA-induced fluorescence, while this fluorescence was much weaker in the necrotic areas of the tumour and in the surrounding normal skin. (C) 1997 Elsevier Science ireland Ltd.
引用
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页码:225 / 231
页数:7
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