Organic Anion Transporting Polypeptide 1B1 (OATP1B1) and OATP1B3: Genetic Variability and Haplotype Analysis in White Canadians

被引：15

作者：

Boivin, Andree-Anne ^{[1
,2
]}

Cardinal, Heloise ^{[3
]}

Barama, Azemi ^{[4
]}

Pichette, Vincent ^{[5
]}

Hebert, Marie-Josee ^{[3
]}

Roger, Michel ^{[1
,2
]}

机构：

[1] Ctr Hosp Univ Montreal, Ctr Rech, Immunogenet Lab, Montreal, PQ, Canada

[2] Univ Montreal, Dept Microbiol & Immunol, Montreal, PQ H3C 3J7, Canada

[3] Ctr Hosp Univ Montreal, Dept Med, Serv Nephrol, Montreal, PQ, Canada

[4] Ctr Hosp Univ Montreal, Dept Chirurg, Serv Chirurg Greffe Renale & Pancreat, Montreal, PQ, Canada

[5] Hop Maison Neuve Rosemont, Serv Nephrol, Dept Med, Montreal, PQ H1T 2M4, Canada

来源：

DRUG METABOLISM AND PHARMACOKINETICS | 2010年 / 25卷 / 05期

关键词：

hepatic transport; ADME; organic anion transport; ethnic differences; genomics; human genetics; single nucleotide polymorphism; OATP; SLC transporters; solute carrier family; SINGLE-NUCLEOTIDE POLYMORPHISMS; C SLC21A6; LINKAGE DISEQUILIBRIUM; JAPANESE SUBJECTS; SLCO1B3; GENE; PHARMACOKINETICS; FREQUENCIES; POPULATION; PHARMACOGENETICS; EXPRESSION;

D O I：

10.2133/dmpk.DMPK-10-SH-046

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Organic anion transporting polypeptide 1B1 (OATP1B1) and OATP1B3 are human hepatocyte transporters that mediate the uptake of various endogenous and exogenous substances Genetic variations in solute carrier transporter 1B1 (SLCO1B1) and SLCO1B3 genes. which encode OATP1B1 and OATP1B3 proteins, could affect the pharmacokinetics of drugs leading to interindividual differences in drug responses. The full extent of SLCO1B1 and SLCO1B3 polymorphisms in white Canadians was analyzed using DNA sequencing procedures We identified 49 and 41 nucleotide sequence variants leading to 10 and 9 major haplotypes in SLCO1B1 and SLCO1B3 genes, respectively We report several novel mutations within regulatory and coding regions that could affect gene transcription, translation and function Comparison with other studies revealed that the distribution of SLCO1B1 and SLCO1B3 polymorphisms and haplotypes differs widely across populations. Data from this survey will ultimately contribute to the design of pharmacogenetic studies in the Canadian population

引用

页码：508 / 515

页数：8

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