TOR signaling: An odyssey from cellular stress to the cell-growth machinery

被引：30

作者：

Abraham, RT ^{[1
]}

机构：

[1] Burnham Inst, Signal Transduct Program, La Jolla, CA 92037 USA

来源：

CURRENT BIOLOGY | 2005年 / 15卷 / 04期

关键词：

D O I：

10.1016/j.cub.2005.02.015

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The target of rapamycin (TOR) protein kinase is centrally involved in the coordination of cell growth and proliferation with the availability of growth factors and nutrients. Two recent reports have illuminated a mechanism whereby hypoxic stress dampens TOR signaling in metazoan cells.

引用

页码：R139 / R141

页数：3

共 17 条

[1] A novel hypoxia-inducible factor-independent hypoxic response regulating mammalian target of rapamycin and its targets [J].

Arsham, AM ;

Howell, JJ ;

Simon, MC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (32) :29655-29660

[2] The TOR pathway: A target for cancer therapy [J].

Bjornsti, MA ;

Houghton, PJ .

NATURE REVIEWS CANCER, 2004, 4 (05) :335-348

[3] Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex [J].

Brugarolas, J ;

Lei, K ;

Hurley, RL ;

Manning, BD ;

Reiling, JH ;

Hafen, E ;

Witter, LA ;

Ellisen, LW ;

Kaelin, WG .

GENES & DEVELOPMENT, 2004, 18 (23) :2893-2904

[4] Regulation of the TSC pathway by LKB1: evidence of a molecular link between tuberous sclerosis complex and Peutz-Jeghers syndrome [J].

Corradetti, MN ;

Inoki, K ;

Bardeesy, N ;

DePinho, RA ;

Guan, KL .

GENES & DEVELOPMENT, 2004, 18 (13) :1533-1538

[5] REDD2 gene is upregulated by modified LDL or hypoxia and mediates human macrophage cell death [J].

Cuaz-Pérolin, C ;

Furman, C ;

Larigauderie, G ;

Legedz, L ;

Lasselin, C ;

Copin, C ;

Jaye, M ;

Searfoss, G ;

Yu, KT ;

Duverger, N ;

Nègre-Salvayre, A ;

Fruchart, JC ;

Rouis, M .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2004, 24 (10) :1830-1835

[6] REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species [J].

Ellisen, LW ;

Ramsayer, KD ;

Johannessen, CM ;

Yang, A ;

Beppu, H ;

Minda, K ;

Oliner, JD ;

McKeon, F ;

Haber, DA .

MOLECULAR CELL, 2002, 10 (05) :995-1005

[7]

Garofalo RS, 2002, TRENDS ENDOCRIN MET, V13, P156, DOI 10.1016/S1043-2760(01)00548-3

[8] TSC2 mediates cellular energy response to control cell growth and survival [J].

Inoki, K ;

Zhu, TQ ;

Guan, KL .

CELL, 2003, 115 (05) :577-590

[9] TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling [J].

Inoki, K ;

Li, Y ;

Zhu, TQ ;

Wu, J ;

Guan, KL .

NATURE CELL BIOLOGY, 2002, 4 (09) :648-657

[10] TOR signalling in bugs, brain and brawn [J].

Jacinto, E ;

Hall, MN .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2003, 4 (02) :117-126

← 1 2 →