Neutrophil kinetics in health and disease

被引：857

作者：

Summers, Charlotte ^{[1
]}

Rankin, Sara M. ^{[2
]}

Condliffe, Alison M. ^{[1
]}

Singh, Nanak ^{[1
]}

Peters, A. Michael ^{[3
]}

Chilvers, Edwin R. ^{[1
]}

机构：

[1] Univ Cambridge, Dept Med, Sch Med, Cambridge CB2 1TN, England

[2] Univ London Imperial Coll Sci Technol & Med, Leukocyte Biol Sect, Natl Heart & Lung Inst, Fac Med, London SW7 2AZ, England

[3] Brighton & Sussex Med Sch, Div Clin & Lab Invest, Brighton, E Sussex, England

来源：

TRENDS IN IMMUNOLOGY | 2010年 / 31卷 / 08期

基金：

英国惠康基金;

关键词：

COLONY-STIMULATING FACTOR; PULMONARY GRANULOCYTE KINETICS; BONE-MARROW; G-CSF; PERIPHERAL-BLOOD; CXCR4; EXPRESSION; PROGENITOR CELLS; FACTOR-RECEPTOR; WHIM-SYNDROME; MICE LACKING;

D O I：

10.1016/j.it.2010.05.006

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Neutrophils play a key role in the elimination of pathogens. They are remarkably short-lived with a circulating half life of 6-8 h and hence are produced at a rate of 5 x 10(10)-10 x 10(10) cells/day. Tight regulation of these cells is vital because they have significant histotoxic capacity and are widely implicated in tissue injury. This review outlines our current understanding of how neutrophils are released from the bone marrow; in particular, the role of the CXC chemokine receptor 4/stromal-derived factor 1 axis, the relative size and role of the freely circulating and marginated (i.e. slowly transiting) pools within the vascular compartment, and the events that result in the uptake and removal of circulating neutrophils. We also review current understanding of how systemic stress and inflammation affect this finely balanced system.

引用

页码：318 / 324

页数：7

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