Inactivation of Pten in osteo-chondroprogenitor cells leads to epiphyseal growth plate abnormalities and skeletal overgrowth

被引：78

作者：

Ford-Hutchinson, Alice Fiona

Ali, Zenobia

Lines, Suzen Elizabeth

Hallgrimsson, Benedikt

Boyd, Steven Kyle

Jirik, Frank Robert

机构：

[1] Univ Calgary, Alberta Bone & Joint Hlth Inst, Dept Biochem & Mol Biol, Calgary, AB, Canada

[2] Univ Calgary, Alberta Bone & Joint Hlth Inst, Dept Cell Biol & Anat, Calgary, AB, Canada

[3] Univ Calgary, Alberta Bone & Joint Hlth Inst, Dept Mech & Mfg Engn, Calgary, AB, Canada

来源：

JOURNAL OF BONE AND MINERAL RESEARCH | 2007年 / 22卷 / 08期

关键词：

Pten; growth plate; conditional knockout; bone overgrowth; Col2aCre;

D O I：

10.1359/JBMR.070420

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

To study the role of the Pten tumor suppressor in skeletogenesis, we generated mice lacking this key phosphatidylinositol 3'-kinase pathway regulator in their osteo-chondroprogenitors. A phenotype of growth plate dysfunction and skeletal overgrowth was observed.

引用

页码：1245 / 1259

页数：15

共 75 条

[1] Deletion of Pten in mouse brain causes seizures, ataxia and defects in soma size resembling Lhermitte-Duclos disease [J].

Backman, SA ;

Stambolic, V ;

Suzuki, A ;

Haight, J ;

Elia, A ;

Pretorius, J ;

Tsao, MS ;

Shannon, P ;

Bolon, B ;

Ivy, GO ;

Mak, TW .

NATURE GENETICS, 2001, 29 (04) :396-403

[2]

BORZI RM, 2004, CLIN ORTHOP RE S OCT, pS53, DOI DOI 10.1097/01.BLO.0000143805.64755.4F

[3]

BRINKERS JM, 1994, EUR J PEDIATR, V153, P237, DOI 10.1007/BF01954509

[4] TSC2 regulates VEGF through mTOR-dependent and -independent pathways [J].

Brugarolas, JB ;

Vazquez, F ;

Reddy, A ;

Sellers, WR ;

Kaelin, WG .

CANCER CELL, 2003, 4 (02) :147-158

[5] Activated parathyroid hormone/parathyroid hormone-related protein receptor in osteoblastic cells differentially affects cortical and trabecular bone [J].

Calvi, LM ;

Sims, NA ;

Hunzelman, JL ;

Knight, MC ;

Giovannetti, A ;

Saxton, JM ;

Kronenberg, HM ;

Baron, R ;

Schipani, E .

JOURNAL OF CLINICAL INVESTIGATION, 2001, 107 (03) :277-286

[6] New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase AKT pathway [J].

Cantley, LC ;

Neel, BG .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1999, 96 (08) :4240-4245

[7] Estrogen receptor-β inhibits skeletal growth and has the capacity to mediate growth plate fusion in female mice [J].

Chagin, AS ;

Lindberg, MK ;

Andersson, N ;

Moverare, S ;

Gustafsson, JÅ ;

Sävendahl, L ;

Ohlsson, C .

JOURNAL OF BONE AND MINERAL RESEARCH, 2004, 19 (01) :72-77

[8] Cellular and molecular interactions regulating skeletogenesis [J].

Colnot, C .

JOURNAL OF CELLULAR BIOCHEMISTRY, 2005, 95 (04) :688-697

[9] Indian hedgehog synchronizes skeletal angiogenesis and perichondrial maturation with cartilage development [J].

Colnot, C ;

de la Fuente, L ;

Huang, S ;

Hu, D ;

Lu, CY ;

St-Jacques, B ;

Helms, JA .

DEVELOPMENT, 2005, 132 (05) :1057-1067

[10] Distinguishing the contributions of the perichondrium, cartilage, and vascular endothelium to skeletal development [J].

Colnot, C ;

Lu, CY ;

Hu, D ;

Helms, JA .

DEVELOPMENTAL BIOLOGY, 2004, 269 (01) :55-69

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