Anti-SSA/Ro antibodies and the heart: more than complete congenital heart block? A review of electrocardiographic and myocardial abnormalities and of treatment options

被引：59

作者：

Costedoat-Chalumeau, N ^{[1
]}

Amoura, Z

Villain, E

Cohen, L

Piette, JC

机构：

[1] CHU Pitie Salpetriere, Serv Med Interne, Paris, France

[2] CHU Necker Enfants Malad, Serv Cardiol Pediat, Paris, France

[3] Inst Jacques Cartier, Serv Cardiol Pediat, Massy, France

来源：

ARTHRITIS RESEARCH & THERAPY | 2005年 / 7卷 / 02期

关键词：

D O I：

10.1186/ar1690

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Apart from complete and incomplete congenital heart block (CHB), new cardiac manifestations related to anti-SSA/Ro antibodies have been reported in children born to mothers bearing these antibodies. These manifestations include transient fetal first-degree heart block, prolongation of corrected QT (QTc) interval, sinus bradycardia, late-onset cardiomyopathy, endocardial fibroelastosis and cardiac malformations. Anti-SSA/Ro antibodies are not considered pathogenic to the adult heart, but a prolongation of the QTc interval has recently been reported in adult patients and is still a matter of debate. Treatment of CHB is not well established and needs to be assessed carefully. The risks and benefits of prenatal fluorinated steroids are discussed.

引用

页码：69 / 73

页数：5

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