Progressive ratio schedules in drug self-administration studies in rats: A method to evaluate reinforcing efficacy

被引：1075

作者：

Richardson, NR ^{[1
]}

Roberts, DCS ^{[1
]}

机构：

[1] CARLETON UNIV,INST NEUROSCI,OTTAWA,ON K1S 5B6,CANADA

来源：

JOURNAL OF NEUROSCIENCE METHODS | 1996年 / 66卷 / 01期

关键词：

drug self-administration; psychomotor stimulant; opiate; progressive ratio; fixed ratio; schedules of reinforcement; drug abuse; INTRAVENOUS COCAINE; RHESUS-MONKEYS; FIXED-RATIO; NUCLEUS-ACCUMBENS; BREAKING POINTS; L-TRYPTOPHAN; PERFORMANCE; BEHAVIOR; METHYLPHENIDATE; AMPHETAMINE;

D O I：

10.1016/0165-0270(95)00153-0

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Drug self-administration studies have recently employed progressive ratio (PR) schedules to examine psychostimulant and opiate reinforcement. This review addresses the technical, statistical, and theoretical issues related to the use of the PR schedule in self-administration studies in rats. Session parameters adopted for use in our laboratory and the considerations relevant to them are described. The strengths and weaknesses of the PR schedule are also discussed.

引用

页码：1 / 11

页数：11

共 71 条

[1] CHOICE BEHAVIOR IN RHESUS-MONKEYS - COCAINE VERSUS FOOD
AIGNER, TG
BALSTER, RL
[J]. SCIENCE, 1978, 201 (4355) : 534 - 535
[2] [Anonymous], CURRENT DEV PSYCHOPH
[3] [Anonymous], NEUROMETH
[4] METHAMPHETAMINE SELF-ADMINISTRATION IN CAT
BALSTER, RL
KILBEY, MM
ELLINWOOD, EH
[J]. PSYCHOPHARMACOLOGIA, 1976, 46 (03): : 229 - 233
[5] FIXED-INTERVAL SCHEDULE OF COCAINE REINFORCEMENT - EFFECT OF DOSE AND INFUSION DURATION
BALSTER, RL
SCHUSTER, CR
[J]. JOURNAL OF THE EXPERIMENTAL ANALYSIS OF BEHAVIOR, 1973, 20 (01) : 119 - 129
[6] COCAINE REINFORCED PROGRESSIVE RATIO PERFORMANCE IN RHESUS-MONKEY
BEDFORD, JA
BAILEY, LP
WILSON, MC
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1978, 9 (05) : 631 - 638
[7] CAREY RJ, 1983, BIOL PSYCHIAT, V18, P249
[8] FLUOXETINE REDUCES INTRAVENOUS COCAINE SELF-ADMINISTRATION IN RATS
CARROLL, ME
LAC, ST
ASENCIO, M
KRAGH, R
[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1990, 35 (01) : 237 - 244
[9] INTRAVENOUS COCAINE SELF-ADMINISTRATION IN RATS IS REDUCED BY DIETARY L-TRYPTOPHAN
CARROLL, ME
LAC, ST
ASENCIO, M
KRAGH, R
[J]. PSYCHOPHARMACOLOGY, 1990, 100 (03) : 293 - 300
[10] CATANIA AC, 1976, PHARMACOL REV, V27, P385

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