The erbB2 gene as a cancer therapeutic target and the tumor- and metastasis-suppressing function of E1A

被引：31

作者：

Yu, DH ^{[1
]}

Hung, MC ^{[1
]}

机构：

[1] Univ Texas, MD Anderson Cancer Ctr, Dept Tumor Biol, Dept Surg Oncol, Houston, TX 77030 USA

来源：

CANCER AND METASTASIS REVIEWS | 1998年 / 17卷 / 02期

关键词：

HER-2/neu; Ad6EIA; gene therapy tumor suppressor;

D O I：

10.1023/A:1006054421970

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In cancer treatment, there are two critical goals among many important issues. One is to identify important therapeutic targets, and the other is to develop new therapeutic agents. In this review, we will focus on (a) identification of the erbB2 (also called HER2 or neu) oncogene as a cancer therapeutic target and (b) the development of the E1A gene as a novel therapeutic agent for tumors that overexpress the erbB2 gene. We wish to provide an example for cancer treatment studies using our own experiences.

引用

页码：195 / 202

页数：8

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