The Kolliker-Fuse nucleus mediates the trigeminally induced apnoea in the rat

被引：70

作者：

Dutschmann, M ^{[1
]}

Herbert, H ^{[1
]}

机构：

[1] UNIV TUBINGEN,D-72076 TUBINGEN,GERMANY

来源：

NEUROREPORT | 1996年 / 7卷 / 08期

关键词：

Kolliker-Fuse; parabrachial; trigeminal; ethmoidal nerve; respiration; asphyxia; diving response; upper airways; autonomic; sudden infant death;

D O I：

10.1097/00001756-199605310-00022

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE present study examined whether the Kolliker-Fuse nucleus (KF) plays a role in mediating the trigeminally induced apnoea which occurs after noxious perturbation of the nasal mucosa. We stimulated the ethmoidal nerve (EN5) electrically and recorded respiratory responses before and after injections of the calcium channel blocker CoCl2 into the KF. Unilateral EN5 stimulations resulted in an apnoea in a reduction of respiratory frequency and tidal volume. EN5 stimulations immediately after ipsilateral CoCl2 injections into the caudal KF caused only minor respiratory suppression, indicating a blockade of synaptic transmission. Recovery of the respiratory responses was observed 15-120 min after the CoCl2 injection. Our data strongly suggest that the caudal KF is an obligatory relay site for trigeminally induced apnoea.

引用

页码：1432 / 1436

页数：5

共 25 条

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