Dopamine mediated iron release from ferritin is enhanced at higher temperatures:: Possible implications for fever induced Parkinson's disease

被引：7

作者：

Babincová, M ^{[1
]}

Babinec, P ^{[1
]}

机构：

[1] Comenius Univ, Dept Biophys & Chem Phys, Bratislava 84248, Slovakia

来源：

JOURNAL OF MAGNETISM AND MAGNETIC MATERIALS | 2005年 / 293卷 / 01期

关键词：

Parkinson's disease; ferritin; dopamine; iron metabolism; oxidative stress; iron release; fever; lipid peroxidation;

D O I：

10.1016/j.jmmm.2005.02.029

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

A new molecular mechanism is proposed to explain the pathogenesis of fever-induced Parkinson's disease. This proposal is based on dopamine and 6-hydroxydopamine-mediated free iron release from ferritin magnetic nanoparticles, which is enhanced at higher temperatures, and which may lead to substantial peroxidation and injury of lipid biomembranes of the substantia nigra in the brain. (c) 2005 Elsevier B.V. All rights reserved.

引用

页码：341 / 344

页数：4

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