Tests of toxicity and teratogenicity in biphasic vertebrates treated with heavy metals (Cr3+, Al3+, Cd2+)

被引：44

作者：

Calevro, F ^{[1
]}

Campani, S ^{[1
]}

Ragghianti, M ^{[1
]}

Bucci, S ^{[1
]}

Mancino, G ^{[1
]}

机构：

[1] Univ Pisa, Dipartimento Fisiol & Biochim, Lab Biol Cellulare & Sviluppo, I-56010 Ghezzano, PI, Italy

来源：

CHEMOSPHERE | 1998年 / 37卷 / 14-15期

关键词：

D O I：

10.1016/S0045-6535(98)00342-7

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 ; 0830 ;

摘要：

Developmental toxicity of chromium(III), aluminium(III) and cadmium(II) were evaluated by examining abnormalities and mortality in embryos belonging to different species of amphibians. Cr(III) and Al(III) are lethal at 1.5 mM concentration, and seriously affect the differentiation of central nervous system, skeleton and eye, and cause cephalic and trunk oedemas at lower concentrations, being aluminium significantly more harmful than chromium. Cd(II), tested only in P. waltl, is highly toxic: embryos exposed to concentrations ranging from 0.18 to 50 mu M display malformations, delay and arrest of development in a dose dependent manner.

引用

页码：3011 / 3017

页数：7

共 26 条

[1]

[Anonymous], 1992, ENV HLTH CRIT

[2]

Berger Leszek, 1994, Amphibia-Reptilia, V15, P408, DOI 10.1163/156853894X00452

[3] Cadmium, gene regulation, and cellular signalling in mammalian cells [J].