In vitro investigation of poor cerebrospinal fluid suppression on fluid-attenuated inversion recovery images in the presence of a gadolinium-based contrast agent

被引：9

作者：

Bonzano, L. ^{[1
,2
]}

Roccatagliata, L. ^{[1
,2
]}

Levrero, F. ^{[3
]}

Mancardi, G. L. ^{[1
,2
]}

Sardanelli, F. ^{[4
]}

机构：

[1] Univ Genoa, DINOG Dept Neurosci Ophthalmol & Genet, I-16132 Genoa, Italy

[2] Univ Genoa, Magnet Resonance Ctr Nervous Syst Dis, I-16132 Genoa, Italy

[3] San Martino Hosp, Dept Med Phys, Genoa, Italy

[4] Univ Milan, Policlin San Donato, Dept Med & Surg Sci, Radiol Unit, Milan, Italy

来源：

MAGNETIC RESONANCE IN MEDICINE | 2008年 / 60卷 / 01期

关键词：

cerebrospinal fluid; fluid-attenuated inversion recovery images; fluid-attenuated inversion recovery (FLAIR); T-1-T-2; relaxation; gadolinium chelate blood-brain barrier;

D O I：

10.1002/mrm.21619

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Cerebrospinal fluid (CSF) enhancement on fluid-attenuated inversion recovery (FLAIR) images obtained post-gadolinium (Gd)-based agent injection is described in stroke and multiple sclerosis. Blood brain barrier (BBB) disruption with contrast agent extravasation into CSF shortens T, relaxation times, reducing fluid suppression. Reduced fluid suppression on FLAIR images was investigated in vitro in the presence of escalating gadopentetate dimeglumine (Gd-DTPA) concentrations mixed with artificial CSF. Low Gd-DTPA concentrations impair fluid suppression of FLAIR imaging in association with progressively reduced T, values. At higher concentrations, the prevalent T-2 shortening effect can explain signal intensity (SI) reduction. Post-Gd FLAIR may be useful in detecting subtle BBB leakage.

引用

页码：220 / 223

页数：4

共 12 条

[1]

Abramoff MD., 2004, Biophot. Int., V11, P36

[2] Cerebrospinal fluid changes after intravenous injection of gadolinium chelate: assessment by FLAIR MR imaging [J].

Bozzao, A ;

Floris, R ;

Fasoli, F ;

Fantozzi, LM ;

Colonnese, C ;

Simonetti, G .

EUROPEAN RADIOLOGY, 2003, 13 (03) :592-597

[3]

Galassi W, 2005, AM J NEURORADIOL, V26, P553

[4] Dysferlin is a new marker for leaky brain blood vessels in multiple sclerosis [J].

Hochmeister, Sonja ;

Grundtner, Roland ;

Bauer, Jan ;

Engelhardt, Britta ;

Lyck, Ruth ;

Gordon, Grace ;

Korosec, Thomas ;

Kutzelnigg, Alexandra ;

Berger, Johannes J. ;

Bradl, Monika ;

Bittner, Reginald E. ;

Lassmann, Hans .

JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 2006, 65 (09) :855-865

[5] Early blood-brain barrier disruption in human focal brain ischemia [J].

Latour, LL ;

Kang, DW ;

Ezzeddine, MA ;

Chalela, JA ;

Warach, S .

ANNALS OF NEUROLOGY, 2004, 56 (04) :468-477

[6] The creatine transporter mediates the uptake of creatine by brain tissue, but not the uptake of two creatine-derived compounds [J].

Lunardi, G. ;

Parodi, A. ;

Perasso, L. ;

Pohvozcheva, A. V. ;

Scarrone, S. ;

Adriano, E. ;

Florio, T. ;

Gandolfo, C. ;

Cupello, A. ;

Burov, S. V. ;

Balestrino, M. .

NEUROSCIENCE, 2006, 142 (04) :991-997

[7]

Mamourian AC, 2000, AM J NEURORADIOL, V21, P105

[8] Brain: Gadolinium-enhanced fast fluid-attenuated inversion-recovery MR imaging [J].

Mathews, VP ;

Caldemeyer, KS ;

Lowe, MJ ;

Greenspan, SL ;

Weber, DM ;

Ulmer, JL .

RADIOLOGY, 1999, 211 (01) :257-263

[9]

MITCHELL DG, 1999, MRI PRINCIPLES

[10] Quantitative assessment of Gd-DTPA contrast agent from signal enhancement:: an in-vitro study [J].

Morkenborg, J ;

Pedersen, M ;

Jensen, FT ;

Stodkilde-Jorgensen, H ;

Djurhuus, JC ;

Frokiær, J .

MAGNETIC RESONANCE IMAGING, 2003, 21 (06) :637-643

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