Umbilical-cord blood transplantation for the treatment of cancer

被引：88

作者：

Barker, JN

Wagner, JE

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Minneapolis, MN 55455 USA

[2] Univ Minnesota, Sch Med, Dept Pediat, Blood & Marrow Transplant Program, Minneapolis, MN 55455 USA

来源：

NATURE REVIEWS CANCER | 2003年 / 3卷 / 07期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc1125

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Haematopoietic stem-cell transplantation is used to treat many haematological cancers, but is limited by the lack of suitable bone-marrow donors, the risk of graft-versus-host disease (GVHD) and slow immune reconstitution. Umbilical-cord blood is an alternative source of haematopoietic stem cells that has recently been tested in both child and adult cancer patients. These studies have identified several advantages to umbilical-cord cell transplantation, including a lower incidence of GVHD. Umbilical-cord blood is therefore a promising alternative to bone-marrow-derived stem cells.

引用

收藏

页码：526 / 532

页数：7

相关论文

共 48 条

[1] Bigger is better: maternal and neonatal predictors of hematopoietic potential of umbilical cord blood units [J].

Ballen, KK ;

Wilson, M ;

Wuu, J ;

Ceredona, AM ;

Hsieh, C ;

Stewart, FM ;

Popovsky, MA ;

Quesenberry, PJ .

BONE MARROW TRANSPLANTATION, 2001, 27 (01) :7-14

[2] Searching for unrelated donor hematopoietic stem cells: Availability and speed of umbilical cord blood versus bone marrow [J].

Barker, JN ;

Krepski, TP ;

DeFor, TE ;

Davies, SM ;

Wagner, JE ;

Weisdorf, DJ .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2002, 8 (05) :257-260

[3] Determinants of survival after human leucocyte antigen-matched unrelated donor bone marrow transplantation in adults [J].

Barker, JN ;

Davies, SM ;

DeFor, TE ;

Burns, LJ ;

McGlave, PB ;

Miller, JS ;

Weisdorf, DJ .

BRITISH JOURNAL OF HAEMATOLOGY, 2002, 118 (01) :101-107

[4]

Barker JN, 2002, BLOOD, V100, p41A

[5]

Barker JN, 2002, BLOOD, V100, p42A

[6] Low incidence of Epstein-Barr virus-associated posttransplantation lymphoproliferative disorders in 272 unrelated-donor umbilical cord blood transplant recipients [J].

Barker, JN ;

Martin, PL ;

Coad, JE ;

DeFor, T ;

Trigg, ME ;

Kurtzberg, J ;

Weisdorf, DJ ;

Wagner, JE .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2001, 7 (07) :395-399

[7] Survival after transplantation of unrelated donor umbilical cord blood is comparable to that of human leukocyte antigen-matched unrelated donor bone marrow: results of a matched-pair analysis [J].

Barker, JN ;

Davies, SM ;

DeFor, T ;

Ramsay, NKC ;

Weisdorf, DJ ;

Wagner, JE .

BLOOD, 2001, 97 (10) :2957-2961

[8] GROWTH-CHARACTERISTICS AND EXPANSION OF HUMAN UMBILICAL-CORD BLOOD AND ESTIMATION OF ITS POTENTIAL FOR TRANSPLANTATION IN ADULTS [J].

BROXMEYER, HE ;

HANGOC, G ;

COOPER, S ;

RIBEIRO, RC ;

GRAVES, V ;

YODER, M ;

WAGNER, J ;

VADHANRAJ, S ;

BENNINGER, L ;

RUBINSTEIN, P ;

BROUN, ER .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (09) :4109-4113

[9]

Broxmeyer HE, 1997, CLIN EXP IMMUNOL, V107, P45

[10] HUMAN UMBILICAL-CORD BLOOD AS A POTENTIAL SOURCE OF TRANSPLANTABLE HEMATOPOIETIC STEM PROGENITOR CELLS [J].

BROXMEYER, HE ;

DOUGLAS, GW ;

HANGOC, G ;

COOPER, S ;

BARD, J ;

ENGLISH, D ;

ARNY, M ;

THOMAS, L ;

BOYSE, EA .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (10) :3828-3832

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