C-reactive protein is a potent predictor of mortality independently of and in combination with troponin T in acute coronary syndromes: A TIMI 11A substudy

Objectives. We evaluated C-reactive protein (CRP) alone and in conjunction with a rapid qualitative assay for cardiac-specific troponin T (cTnT) for predicting 14-day mortality in patients with unstable angina or non-Q wave myocardial infarction (NQMI). Background. Elevated CRP has been found to correlate with higher risk for cardiac events in patients with coronary disease. Methods. At enrollment into the Thrombolysis In Myocardial Infarction (TIMI) 11A trial, a dose-ranging trial of enoxaparin for unstable angina and NQMT, serum was obtained Tor CRP measurement and rapid cTnT assay. Results. Quantitative CRP and rapid cThT assays mere performed in all patients. CRP was higher among patients who died than in survivors (7.2 vs. 1.3 mg/dl, p = 0.0038). The probability of a positive rapid cTnT assay rose with increasing CRP concentration (p < 0.0001). Among patients with a negative rapid cTnT assay, the mortality rate was higher among patients with CRP greater than or equal to 1.55 mg/dl (5.80% vs. 0.36%, p = 0.006). Patients with both an early positive sapid cTnT assay (less than or equal to 10 min until assay positive) and CRP greater than or equal to 1.55 mg/dl had the highest mortality, followed by those with either CRP greater than or equal to 1.55 mg/dl or an early positive rapid cTnT assay, whereas patients with both a negative rapid cTnT assay and CRP <1.55 mg/dl were at very low risk (9.10% vs, 4.65% vs. 0.36%, p = 0.0003). Conclusions. Elevated CRP at presentation in patients dth unstable angina or NQMI is correlated with increased 14-day mortality, even in patients with a negative rapid cTnT assay. Quantitative CRP and a rapid cTnT assay provide complementary information for stratifying patients with regard to mortality risk. (C) 1998 by the American College of Cardiology.