Review of current treatment in panic disorder

被引:24
作者
den Boer, JA [1 ]
Slaap, BR [1 ]
机构
[1] Acad Hosp Groningen, Psychiat Univ Clin, NL-9700 RB Groningen, Netherlands
关键词
anxiety; benzodiazepines; panic attacks; panic disorder; selective serotonin reuptake inhibitors; tricyclic antidepressants;
D O I
10.1097/00004850-199804004-00005
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The ideal properties for an antipanic agent include the ability to provide complete recovery from panic attacks, resolution of associated anxiety and avoidance behavior, relapse prevention, good tolerability, and efficacy in comorbid conditions including depression. We compared the properties of currently available treatment options for panic attacks, including the benzodiazepines, tricyclic antidepressants, monoamine oxidase inhibitors and selective serotonin reuptake inhibitors (SSRIs), with this ideal. Experimental approaches in the development of therapeutic agents of potential use against panic disorder were also examined. It is clear that SSRIs, such as paroxetine, are an effective treatment for panic disorder, and their antidepressant activity also allows concurrent treatment of comorbid depressive disorders, for which patients with panic disorder are at high risk. However, despite the availability of effective antipanic agents, some patients do not respond to treatment. (C) 1998 Lippincott-Raven Publishers.
引用
收藏
页码:S25 / S30
页数:6
相关论文
共 52 条
[1]  
Association A.P., 1987, Diagnostic and Statistical Manual of Mental Disorders-Revision
[2]  
Bakish D, 1996, PSYCHOPHARMACOL BULL, V32, P135
[3]   Comorbidity of panic and depression: implications for clinical management [J].
Ballenger, JC .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1998, 13 :S13-S17
[4]  
BALLENGER JC, 1993, PSYCHOPHARMACOL BULL, V29, P477
[5]  
BLACK DW, 1993, ARCH GEN PSYCHIAT, V50, P44
[6]   PREDICTORS OF SHORT-TERM TREATMENT RESPONSE IN 66 PATIENTS WITH PANIC DISORDER [J].
BLACK, DW ;
WESNER, RB ;
GABEL, J ;
BOWERS, W ;
MONAHAN, P .
JOURNAL OF AFFECTIVE DISORDERS, 1994, 30 (04) :233-241
[7]  
BRADWEJN J, 1991, ARCH GEN PSYCHIAT, V48, P603
[8]  
BRADWEJN J, 1994, ARCH GEN PSYCHIAT, V51, P486
[9]   DRUG-TREATMENT OF PANIC DISORDER - COMPARATIVE EFFICACY OF ALPRAZOLAM, IMIPRAMINE, AND PLACEBO [J].
COLEMAN, JH ;
KLERMAN, GL ;
AYUSO, JL ;
BECH, P ;
BENKERT, O ;
BRANDON, S ;
CASSANO, GB ;
SILVA, JACE ;
CURTIS, GC ;
DELAFUENTE, JR ;
GUIMON, J ;
HIPPIUS, H ;
LECRUBIER, Y ;
LEON, CA ;
LOPEZIBOR, JJ ;
KATSCHNIG, H ;
MASSANA, J ;
MELLERGAARD, M ;
OTTOSON, JO ;
RAFAELSEN, OJ ;
ROSENBERG, R ;
ROTH, M ;
SEPULVEDA, J ;
SOLYOM, L ;
VERSIANI, M ;
WILMOTTE, J .
BRITISH JOURNAL OF PSYCHIATRY, 1992, 160 :191-202
[10]  
DEBEURS E, 1995, AM J PSYCHIAT, V152, P683