Unveiling the enigma of the CNS as a B-cell fostering environment

被引：65

作者：

Uccelli, A ^{[1
]}

Aloisi, F

Pistoia, V

机构：

[1] Univ Genoa, Dept Neurosci Ophthalmol & Genet, Neuroimmunol Unit, I-16126 Genoa, Italy

[2] Univ Genoa, Ctr Excellence Biomed Res, I-16126 Genoa, Italy

[3] Ist Super Sanita, Dept Cell Biol & Neurosci, I-00161 Rome, Italy

[4] G Gaslini Inst Children, Lab Oncol, Genoa, Italy

来源：

TRENDS IN IMMUNOLOGY | 2005年 / 26卷 / 05期

关键词：

D O I：

10.1016/j.it.2005.02.009

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This Opinion deals with the apparent paradox between the 'immune privileged' status of the central nervous system (CNS) and its propensity to act as a B-cell fostering environment in a variety of neurological disorders. Evidence will be reviewed that: (i) molecules regulating B-cell homing and survival are produced in the CNS, (ii) in different neuroinflammatory diseases, B cells can undergo a local recapitulation of the differentiation occurring in secondary lymphoid organs and (iii) ectopic lymphoid follicles develop in the meninges of multiple sclerosis (MS) patients.

引用

页码：254 / 259

页数：6

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