Pneumococcal conjugate vaccine does not influence Staphylococcus aureus carriage in young children with acute otitis media

被引：28

作者：

Cohen, Robert ^{[1
,2
]}

Levy, Corinne ^{[2
]}

Thollot, Franck ^{[3
]}

De la Rocque, France ^{[2
]}

Koskas, Marc ^{[2
]}

Bonnet, Eric ^{[4
]}

Fritzell, Bernard ^{[4
]}

Varon, Emmanuelle ^{[5
]}

机构：

[1] Ctr Hosp Intercommunal, Microbiol Serv, F-94000 Creteil, France

[2] Assoc Clin & Therapeut Infantile Val Marne, St Maur des Fosses, France

[3] Assoc Francaise Pediat Ambulatoire, Esseys Les Nancy, France

[4] Wyeth Pharmaceut France, La Defense, France

[5] Hosp Eruopeen Georges Pompidou, Assistance Publ Hosp, Natl Reference Ctr Pneumococci, Paris, France

来源：

CLINICAL INFECTIOUS DISEASES | 2007年 / 45卷 / 12期

关键词：

D O I：

10.1086/523734

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We investigated nasopharyngeal carriage of Streptococcus pneumoniae and Staphylococcus aureus among infants and young children with acute otitis media in a country where use of 7-valent pneumococcal conjugate vaccine (PCV7) has been progressively implemented. Among 1783 children enrolled, 60.8% carried S. pneumoniae, and 9% carried S. aureus. Among S. pneumoniae carriers, the rate of S. aureus carriage was 8.4%, compared with 9.9% among S. pneumoniae noncarriers. The rate of S. pneumoniae carriage in the PCV7-vaccinated population was lower (59.8%) than that observed in the nonvaccinated population (66.2%; P <.04). In contrast, in young children (age, < 2 years) with acute otitis media, our study suggests that the S. aureus carriage rate is not affected by PCV7 immunization (9.0% in vaccinated children vs. 8.7% in nonvaccinated children). Furthermore, in children aged > 1 year, the booster dose induces a sharp reduction in the carriage of vaccine serotypes of S. pneumoniae, without any change in S. aureus carriage.

引用

页码：1583 / 1587

页数：5

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