Shifting the balance: antibiotic effects on host-microbiota mutualism

被引：561

作者：

Willing, Benjamin P. ^{[1
]}

Russell, Shannon L. ^{[1
,2
]}

Finlay, B. Brett ^{[1
,2
]}

机构：

[1] Univ British Columbia, Michael Smith Labs, Vancouver, BC V6T 1Z4, Canada

[2] Univ British Columbia, Dept Microbiol & Immunol, Vancouver, BC V6T 1Z4, Canada

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 04期

基金：

加拿大健康研究院;

关键词：

CHAIN FATTY-ACIDS; DIFFICILE-ASSOCIATED DISEASE; INTESTINAL IMMUNE-RESPONSES; SYSTEMIC INNATE IMMUNITY; HUMAN FECAL MICROBIOTA; NECROSIS-FACTOR-ALPHA; GUT MICROBIOTA; CLOSTRIDIUM-DIFFICILE; MOUSE MODEL; T-CELLS;

D O I：

10.1038/nrmicro2536

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Antibiotics have been used effectively as a means to treat bacterial infections in humans and animals for over half a century. However, through their use, lasting alterations are being made to a mutualistic relationship that has taken millennia to evolve: the relationship between the host and its microbiota. Host-microbiota interactions are dynamic; therefore, changes in the microbiota as a consequence of antibiotic treatment can result in the dysregulation of host immune homeostasis and an increased susceptibility to disease. A better understanding of both the changes in the microbiota as a result of antibiotic treatment and the consequential changes in host immune homeostasis is imperative, so that these effects can be mitigated.

引用

页码：233 / 243

页数：11

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