Photoperiod differentially regulates circadian oscillators in central and peripheral tissues of the Syrian hamster

被引:67
作者
Carr, AJF [1 ]
Johnston, JD [1 ]
Semikhodskii, AG [1 ]
Nolan, T [1 ]
Cagampang, FRA [1 ]
Stirland, JA [1 ]
Loudon, ASI [1 ]
机构
[1] Univ Manchester, Sch Biol Sci, Manchester M13 9P, Lancs, England
基金
英国生物技术与生命科学研究理事会;
关键词
D O I
10.1016/S0960-9822(03)00619-5
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
In many seasonally breeding rodents, reproduction and metabolism are activated by long summer days (LD) and inhibited by short winter days (SD) [1]. After several months of SD, animals become refractory to this inhibitory photoperiod and spontaneously revert to LD-like physiology [2, 3]. The suprachiasmatic nuclei (SCN) house the primary circadian oscillator in mammals [4]. Seasonal changes in photic input to this structure control many annual physiological rhythms via SCN-regulated pineal melatonin secretion, which provides an internal endocrine signal representing photoperiod [1]. We compared LD- and SD-housed animals and show that the waveform of SCN expression for three circadian clock genes (Per1, Per2, and Cry2) is modified by photoperiod. In SD-refractory (SD-R) animals, SCN and melatonin rhythms remain locked to SD, reflecting ambient photoperiod, despite LD-like physiology. In peripheral oscillators, Per1 and Dbp rhythms are also modified by photoperiod but, in contrast to the SCN, revert to LD-like, high-amplitude rhythms in SD-R animals. Our data suggest that circadian oscillators in peripheral organs participate in photoperiodic time measurement in seasonal mammals; however, circadian oscillators operate differently in the SCN. The clear dissociation between SCN and peripheral oscillators in refractory animals implicates intermediate factor(s), not directly driven by the SCN or melatonin, in entrainment of peripheral clocks.
引用
收藏
页码:1543 / 1548
页数:6
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