Mammalian sterile 20-like kinases in tumor suppression: An emerging pathway

被引：44

作者：

O'Neill, EE

Matallanas, D

Kolch, W

机构：

[1] Beatson Inst Canc Res, Glasgow G61 1BD, Lanark, Scotland

[2] Univ Glasgow, Inst Biomed & Life Sci, Glasgow, Lanark, Scotland

来源：

CANCER RESEARCH | 2005年 / 65卷 / 13期

关键词：

D O I：

10.1158/0008-5472.CAN-05-1453

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Emerging evidence suggests that the proapoptotic kinase mammalian sterile 20-like kinase 2 (MST2) acts in a novel tumor suppression pathway. Recently, we showed that Raf-I kinase sequesters and inhibits MST2 and that this event is critical for Raf-mediated cell survival. In this review, we summarize Raf control of MST2 and we outline a novel pathway involving the downstream effector proteins Salvador and Warts/Lats that may act to limit the positive effects of Raf-mitogen-activated protein kinase signaling in cancer cells.

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收藏

页码：5485 / 5487

页数：3

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