Using concepts in literature-based discovery: Simulating Swanson's Raynaud-fish oil and migraine-magnesium discoveries

被引：142

作者：

Weeber, M

Klein, H

de Jong-van den Berg, LTW

Vos, R

机构：

[1] Univ Groningen, Inst Drug Explorat, NL-9713 AV Groningen, Netherlands

[2] Univ Maastricht, Fac Hlth Sci, NL-6200 MD Maastricht, Netherlands

[3] Ctr Language & Cognit Groningen, Dept Humanities Comp, NL-9700 AS Groningen, Netherlands

来源：

JOURNAL OF THE AMERICAN SOCIETY FOR INFORMATION SCIENCE AND TECHNOLOGY | 2001年 / 52卷 / 07期

关键词：

D O I：

10.1002/asi.1104

中图分类号：

TP [自动化技术、计算机技术];

学科分类号：

0812 ;

摘要：

Literature-based discovery has resulted in new knowledge. In the biomedical context, Don R. Swanson has generated several literature-based hypotheses that have been corroborated experimentally and clinically. In this paper, we propose a two-step model of the discovery process in which hypotheses are generated and subsequently tested. We have implemented this model in a Natural Language Processing system that uses biomedical Unified Medical Language System (UMLS) concepts as its unit of analysis. We use the semantic information that is provided with these concepts as a powerful filter to successfully simulate Swanson's discoveries of connecting Raynaud's disease with fish oil and migraine with a magnesium deficiency.

引用

页码：548 / 557

页数：10

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