Primary gastric lymphomas: Morphologic, immunohistochemical and immunogenetic analyses

被引：16

作者：

Narita, M ^{[1
]}

Yatabe, Y ^{[1
]}

Asai, J ^{[1
]}

Mori, N ^{[1
]}

机构：

[1] AICHI CANC CTR HOSP,PATHOL SECT,NAGOYA,AICHI,JAPAN

来源：

PATHOLOGY INTERNATIONAL | 1996年 / 46卷 / 09期

关键词：

CALLA; gastric lymphoma; immunohistochemistry; MALT lymphoma;

D O I：

10.1111/j.1440-1827.1996.tb03664.x

中图分类号：

R36 [病理学];

学科分类号：

100104 ;

摘要：

Morphologic, immunohistochemical and immunogenetic studies were performed on 28 cases of primary gastric lymphoma from fresh frozen tissue. Eight cases were diagnosed as diffuse large B-cell lymphoma, four as follicular center lymphoma (follicular), five as mucosa-associated lymphoid tissue (MALT) lymphoma, three as plasmacytoma, and three as T-cell lymphoma, two as mantle cell lymphoma, one as follicular center lymphoma (diffuse, predominantly small cell), and one as lymphoplasmacytoid lymphoma, and one as Hodgkin's disease. From immunohistochemical studies, four types of morphologically similar low-grade lymphomas can be differentiated by a combination of various monoclonal antibodies. Cases of diffuse large B-cell lymphoma may have a germinal center origin. We observed lympho-epithelial lesions in cases of non-MALT lymphomas. We therefore consider that the current diagnostic criterion for MALT lymphoma may not always be valid. Except for cases of T-cell lymphoma and Hodgkin's disease, 17 out of 22 cases revealed clonal rearrangement bands of the JH gene. In situ hybridization (ISH) and polymerase chain reaction (PCR) studies revealed the presence of Epstein-Barr (EB) virus genomes in two and three cases, respectively. Epstein-Barr virus may play a role in lymphomagenesis, although on relatively rare occasions.

引用

页码：623 / 629

页数：7

共 49 条

[1] PRIMARY GASTRIC T-CELL LYMPHOMA OF SUPPRESSOR-CYTOTOXIC (CD8+) PHENOTYPE - DISCORDANT EXPRESSION OF T-CELL RECEPTOR SUBUNIT-BETA-F1, CD7, AND CD3 ANTIGENS [J].