Binding of β-carbolines at 5-HT2 serotonin receptors

被引：52

作者：

Grella, B

Teitler, M

Smith, C

Herrick-Davis, K

Glennon, RA ^{[1
]}

机构：

[1] Virginia Commonwealth Univ, Dept Med Chem, Sch Pharm, Richmond, VA 23298 USA

[2] Albany Med Coll, Ctr Neuropharmacol & Neurosci, Albany, NY 12208 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 24期

关键词：

D O I：

10.1016/j.bmcl.2003.09.027

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of ring-substituted (i.e., methoxy and bromo) 3,4-dihydro- and 1,2,3,4-tetrahydro-beta-carbolines was examined at 5-HT2A and 5-HT2C serotonin receptors. Whereas most of the methoxy- substituted derivatives typically displayed affinities similar to their unsubstituted parents, certain (particularly 8-substituted) bromo derivatives displayed enhanced affinity. A binding profile was obtained for selected beta-carbolines. (C) 2003 Elsevier Ltd. All rights reserved.

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页码：4421 / 4425

页数：5

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