Carbonic anhydrase inhibitors .36. Inhibition of isozymes I and II with Schiff bases derived from chalkones and aromatic/heterocyclic sulfonamides

被引：68

作者：

Supuran, CT ^{[1
]}

Popescu, A ^{[1
]}

Ilisiu, M ^{[1
]}

Costandache, A ^{[1
]}

Banciu, MD ^{[1
]}

机构：

[1] POLYTECH UNIV BUCHAREST,ORGAN CHEM LAB,BUCHAREST,ROMANIA

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 1996年 / 31卷 / 06期

关键词：

sulfonamide; carbonic anhydrase; Schiff base; enzyme inhibition;

D O I：

10.1016/0223-5234(96)85164-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of 27 Schiff bases was prepared by reaction of chalkones with sulfanilamide and 5-amino-1,3,4-thiadiazole-2-sulfonamide. The new compounds were characterized by analysis and standard physico-chemical methods. They possess good inhibitory properties towards isozymes I and II of carbonic anhydrase. Structure-activity effects in this series of inhibitors are also discussed.

引用

页码：439 / 447

页数：9

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