Structure of astacin with a transition-state analogue inhibitor

被引：139

作者：

Grams, F

Dive, V

Yiotakis, A

Yiallouros, I

Vassiliou, S

Zwilling, R

Bode, W

Stocker, W

机构：

[1] UNIV HEIDELBERG,INST ZOOL,D-69120 HEIDELBERG,GERMANY

[2] MAX PLANCK INST BIOCHEM,ABT STRUKTURFORSCH,D-82152 PLANEGG,GERMANY

[3] CENS,CEA,DEPT INGN& ETUD PROT,F-91191 GIF SUR YVETTE,FRANCE

[4] UNIV ATHENS,DEPT ORGAN CHEM,ZOGRATU 15771,ATHENS,GREECE

来源：

NATURE STRUCTURAL BIOLOGY | 1996年 / 3卷 / 08期

关键词：

D O I：

10.1038/nsb0896-671

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The structure of the zinc peptidase astacin in complex with a phosphinic peptide suggests that a special role is played by the side chain of a zinc-bound tyrosine, which is shifted to form bond to the phosphinyl group-a mimic of the carboxyanion of the transition state.

引用

页码：671 / 675

页数：5

共 29 条

[1] Auld D.S., 1987, HYDROLYTIC ENZYMES, P201
[2] EVALUATION OF INTRINSIC BINDING-ENERGY FROM A HYDROGEN-BONDING GROUP IN AN ENZYME-INHIBITOR
BARTLETT, PA
MARLOWE, CK
[J]. SCIENCE, 1987, 235 (4788) : 569 - 571
[3] 3-DIMENSIONAL STRUCTURE OF THE ALKALINE PROTEASE OF PSEUDOMONAS-AERUGINOSA - A 2-DOMAIN PROTEIN WITH A CALCIUM-BINDING PARALLEL-BETA ROLL MOTIF
BAUMANN, U
WU, S
FLAHERTY, KM
MCKAY, DB
[J]. EMBO JOURNAL, 1993, 12 (09) : 3357 - 3364
[4] CRYSTAL-STRUCTURE OF THE 50 KDA METALLOPROTEASE FROM SERRATIA-MARCESCENS
BAUMANN, U
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1994, 242 (03) : 244 - 251
[5] CRYSTAL-STRUCTURE OF A COMPLEX BETWEEN SERRATIA-MARCESCENS METALLOPROTEASE AND AN INHIBITOR FROM ERWINIA-CHRYSANTHEMI
BAUMANN, U
BAUER, M
LETOFFE, S
DELEPELAIRE, P
WANDERSMAN, C
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1995, 248 (03) : 653 - 661
[6] THE ROLE OF HISTIDINE-231 IN THERMOLYSIN-LIKE ENZYMES - A SITE-DIRECTED MUTAGENESIS STUDY
BEAUMONT, A
ODONOHUE, MJ
PAREDES, N
ROUSSELET, N
ASSICOT, M
BOHUON, C
FOURNIEZALUSKI, MC
ROQUES, BP
[J]. JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (28) : 16803 - 16808
[7] STRUCTURE OF ASTACIN AND IMPLICATIONS FOR ACTIVATION OF ASTACINS AND ZINC-LIGATION OF COLLAGENASES
BODE, W
GOMISRUTH, FX
HUBER, R
ZWILLING, R
STOCKER, W
[J]. NATURE, 1992, 358 (6382) : 164 - 167
[8] THE ASTACIN FAMILY OF METALLOENDOPEPTIDASES
BOND, JS
BEYNON, RJ
[J]. PROTEIN SCIENCE, 1995, 4 (07) : 1247 - 1261
[9] CRYSTALLOGRAPHIC REFINEMENT BY SIMULATED ANNEALING - APPLICATION TO CRAMBIN
BRUNGER, AT
KARPLUS, M
PETSKO, GA
[J]. ACTA CRYSTALLOGRAPHICA SECTION A, 1989, 45 : 50 - 61
[10] CARBOXYPEPTIDASE-A
CHRISTIANSON, DW
LIPSCOMB, WN
[J]. ACCOUNTS OF CHEMICAL RESEARCH, 1989, 22 (02) : 62 - 69

← 1 2 3 →