A viral mechanism for inhibition of the cellular phosphatase calcineurin

被引：117

作者：

Miskin, JE ^{[1
]}

Abrams, CC ^{[1
]}

Goatley, LC ^{[1
]}

Dixon, LK ^{[1
]}

机构：

[1] AFRC, Inst Anim Hlth, Pirbright Lab, Pirbright GU24 0NF, Surrey, England

来源：

SCIENCE | 1998年 / 281卷 / 5376期

关键词：

D O I：

10.1126/science.281.5376.562

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The transcription factor NFAT (nuclear factor of activated T cells) controls the expression of many immunomodulatory proteins. African swine Fever virus inhibits proinflammatory cytokine expression in infected macrophages, and a viral protein A238L was found to display the activity of the immunosuppressive drug cyclosporin A by inhibiting NFAT-regulated gene transcription in vivo. This it does by binding the catalytic subunit of calcineurin and inhibiting calcineurin phosphatase activity.

引用

页码：562 / 565

页数：4

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