Cytomegalovirus Viruria and DNAemia in Healthy Seropositive Women

被引:40
作者
Arora, Nitin [1 ,3 ]
Novak, Zdenek [1 ]
Fowler, Karen B. [1 ,2 ,3 ]
Boppana, Suresh B. [1 ,4 ]
Ross, Shannon A. [1 ]
机构
[1] Univ Alabama, Dept Pediat, Birmingham, AL 35233 USA
[2] Univ Alabama, Dept Epidemiol, Birmingham, AL 35233 USA
[3] Univ Alabama, Dept Maternal & Child Hlth, Birmingham, AL 35233 USA
[4] Univ Alabama, Dept Microbiol, Birmingham, AL 35233 USA
关键词
PREEXISTING IMMUNITY; INFECTION; POPULATION; CHILDREN; INFANTS; MOTHERS; SWEDEN; BLOOD; BORN;
D O I
10.1086/657412
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Viruria and DNAemia patterns were investigated in 205 seroimmune women enrolled in a prospective cytomegalovirus (CMV) reinfection study. CMV DNA was detected at least once in urine and blood specimens from 83% and 52% of patients, respectively. At baseline, 39% of patients had viruria, and 24% had DNAemia. Intermittent viruria and viremia was observed throughout the study. There were no differences in baseline CMV positivity by polymerase chain reaction or in longitudinal DNAemia and viruria between the women with and without serological evidence of reinfection. In young seropositive women, CMV DNAemia and viruria are common, which suggests that naturally acquired immunity to CMV does not alter shedding patterns.
引用
收藏
页码:1800 / 1803
页数:4
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