Synthesis and electron-transfer reactions of some 3-difluoroacetylated imidazo[1,2-α]pyridine derivatives

被引:26
作者
Burkholder, C
Dolbier, WR
Médebielle, M
Ait-Mohand, S
机构
[1] Univ Paris 07, Lab Electrochim Mol, CNRS, UMR, F-75251 Paris 05, France
[2] Univ Florida, Dept Chem, Gainesville, FL 32611 USA
关键词
imidazo[1,2-alpha]pyridine; cyclic voltammetry tetrakis(dimethylamino)ethylene; fluorine and compounds;
D O I
10.1016/S0040-4039(01)00388-4
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The synthesis of new 3-chlorodifluoroacetylated imidazo[l,2-a]pyridines 1-6 and their difluoroacetyl derivatives is presented. The reductive cleavage of the halogenated ketones was investigated by cyclic voltammetry, and tetrakis(dimethylamino)ethylene (TDAE) was found to be an effective reductant for the generation of the corresponding alpha,alpha -difluoroacetyl anions and for the synthesis of new gem-difluoromethylated imidazo[1,2-a]pyridine derivatives 7-12. (C) 2001 Elsevier Science Ltd. All rights reserved.
引用
收藏
页码:3077 / 3080
页数:4
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