NTE-122, an acyl-CoA:cholesterol acyltransferase inhibitor, prevents the progression of atherogenesis in cholesterol-fed rabbits

被引:14
作者
Azuma, Y [1 ]
Date, K [1 ]
Ohno, K [1 ]
Matsushiro, S [1 ]
Nobuhara, Y [1 ]
Yamada, T [1 ]
机构
[1] Nissin Food Prod Co Ltd, Cent Res Inst, Shiga 5250055, Japan
关键词
NTE-122; acyl-CoA : cholesterol acyltransferase (ACAT) inhibitor; atherosclerosis;
D O I
10.1254/jjp.86.120
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The cholesterol-lowering and anti-atherosclerotic effects of NTE-122 (trans-1,4-bis[[1-cyclohexyl-3-(4-dimethylaminophenyl)ureido]methyl]cyclohexane). an acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor, were evaluated in 1% cholesterol diet-fed rabbits. NTE-122 (1, 3 and 10 mg/kg per day) lowered the total cholesterol levels in both plasma and liver dose-dependently (by 99% and 94% at 10 mg/kg per day, respectively). In the aortic wall of the rabbits given NTE-122, the atherosclerotic lesion area in both aortic arch and thoracic aorta were dose-dependently reduced (by 100% at 10 mg/kg per day), and the total cholesterol content in aortic arch was also lowered significantly at more than 3 mg/kg per day. These results suggest that NTE-122 is capable of exhibiting anti-atherosclerotic effects.
引用
收藏
页码:120 / 123
页数:4
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