Evaluation of Nrf2 and IGF-1 expression in benign, premalignant and malignant gastric lesions

被引：45

作者：

Wang, Hong-Bo ^{[1
]}

Zhou, Cheng-Jun ^{[1
]}

Song, Su-zhen ^{[2
]}

Chen, Peng ^{[1
]}

Xu, Wei-hua ^{[1
]}

Liu, Bin ^{[1
]}

Zhu, Kong-xi ^{[1
]}

Yu, Wei-hua ^{[1
]}

Wu, Hong-lei ^{[1
]}

Wang, Hong-juan ^{[1
]}

Lin, Sen ^{[1
]}

Guo, Jian-qiang ^{[1
]}

Qin, Cheng-yong ^{[3
]}

机构：

[1] Shandong Univ, Dept Digest Dis, Hosp 2, Jinan 250033, Shandong, Peoples R China

[2] Shandong Univ Tradit Chinese Med, Dept Digest Dis, Hosp 2, Jinan 250001, Shandong, Peoples R China

[3] Shandong Univ, Shandong Prov Hosp, Dept Digest Dis, Jinan 250021, Shandong, Peoples R China

来源：

PATHOLOGY RESEARCH AND PRACTICE | 2011年 / 207卷 / 03期

关键词：

Nuclear factor erythroid2-related factor (Nrf2); Insulin-like growth factor-1 (IGF-1); Gastric adenocarcinoma; Carcinogenes; TRANSCRIPTION FACTOR NRF2; CALORIC RESTRICTION; DIETARY RESTRICTION; INSULIN; MICE; CARCINOMA; RECEPTOR; GROWTH; CANCER; GENES;

D O I：

10.1016/j.prp.2010.12.009

中图分类号：

R36 [病理学];

学科分类号：

100103 [病原生物学];

摘要：

The aim of this study was to investigate the expression of Nrf2 and IGF-1 in benign, premalignant, and malignant gastric lesions, and to explore the role of Nrf2 and IGF-1 in gastric carcinoma carcinogenesis. Nrf2 and IGF-1 expression was detected in normal gastric mucosa, hyperplastic polyp, intraepithelial neoplasia, and adenocarcinoma by immunohistochemistry. There was no expression of Nrf2 and IGF-1 in normal gastric mucous membrane. With the elevation of Nrf2, IGF-1 expression, their co-expressions were highly elevated from benign proliferative lesions to malignant lesions. There were significant differences between hyperplastic polyps, intraepithelial neoplasias, and adenocarcinoma (hyperplastic polys vs. intraepithelial neoplasia: P = 0.012; hyperplastic polyps vs. adenocarcinoma: P = 0.023; and intraepithelial neoplasia vs. adenocarcinoma: P = 0.027; hyperplastic polyps vs. adenocarcinoma: P = 0.0000, respectively). Nrf2 expression and IGF-1 expression were correlated positively (r = 0.337, P = 0.037). The increased expression of Nrf2 and IGF-1 may be related to gastric carcinogenesis. Elevated Nrf2 and IGF-1 may play important roles in promoting tumor progression. (C) 2011 Published by Elsevier GmbH.

引用

页码：169 / 173

页数：5

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