Hyper-reactive Malarial Splenomegaly (HMS) in malaria endemic area in Eastern Sudan

被引：11

作者：

Allam, Mushal M. ^{[1
]}

Alkadarou, Tayseer A. M. Y. ^{[1
]}

Ahmed, Bashir G. ^{[2
]}

Elkhair, Ikhlas S. ^{[2
]}

Alansary, Elhassan H. ^{[3
]}

Ibrahim, Muntasir E. ^{[1
]}

Elhassan, Ahmed M. ^{[1
]}

Elhassan, Ibrahim M. ^{[1
]}

机构：

[1] Univ Khartoum, Inst Endem Dis, Khartoum, Sudan

[2] Kassala Teaching Hosp, Kassala, Kassala State, Sudan

[3] Kassala Univ, Fac Med, Kassala, Kassala State, Sudan

来源：

ACTA TROPICA | 2008年 / 105卷 / 02期

关键词：

hyper-reactive malarial splenomegaly; tropical splenomegaly syndrome; Eastern Sudan; malaria;

D O I：

10.1016/j.actatropica.2007.10.002

中图分类号：

R38 [医学寄生虫学]; Q [生物科学];

学科分类号：

07 [理学]; 0710 [生物学]; 09 [农学]; 100103 [病原生物学];

摘要：

Hyper-reactive Malarial Splenomegaly (HMS) is massive enlargement of the spleen resulting from abnormal immune response to repeated attacks of malaria. The present study was carried out in Kassala city, Eastern Sudan where HMS is considered as highly prevalent. The objectives of this study were to determine the incidence of HMS in Eastern Sudan, and to identify basic laboratory and clinical characteristics of this condition in Sudanese patients. In the period between January and March 2004, a cross-sectional study was carried out in four health centers in Kassala city. In the current study 114 out 1010 (11%) medical cases examined were found to have enlarged spleens, 87 (9%) of them were diagnosed as HMS. Sixty-three percent of HMS cases were males and the rest were females. The mean age of HMS patients was 28 years. Clinical investigations showed that all cases suffered from abdominal pain in the upper left quadrant and all had a palpable firm spleen (10-26cm) below the costal margin. Laboratory examinations showed that 74% of the cases were anaemic and the mean white blood count for all cases was 4237 cell/mL(3). Serum concentration of IgM in all subjects was above the threshold of the mean value plus 2 S.D. for 35 asymptomatic controls. In more than 70% of the HMS patients (53 individuals) the spleens were impalpable after the third month of the treatment. Our data indicate that HMS is one of the major causes of tropical splenomegaly in Eastern Sudan. (C) 2007 Elsevier B.V. All rights reserved.

引用

页码：196 / 199

页数：4

共 25 条

[1]

[Anonymous], PRACTICAL HAEMATOLOG

[2]

Causes of massive tropical splenomegaly in Ghana [J].