Sequence-selective peptide detection by small synthetic chemosensors selected from an encoded combinatorial chemosensor library

被引：14

作者：

Iorio, EJ ^{[1
]}

Shao, YF ^{[1
]}

Chen, CT ^{[1
]}

Wagner, H ^{[1
]}

Still, WC ^{[1
]}

机构：

[1] Columbia Univ, Dept Chem, New York, NY 10027 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2001年 / 11卷 / 13期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S0960-894X(01)00236-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Synthetic chemosensors hold great potential in many diagnostic applications. In this study, we describe the design and preparation of the first encoded combinatorial library of chemosensors for tripeptides. Subsequent screening of the library resulted in the discovery of novel chemosensors able to distinguish between random tripeptides. (C) 2001 Elsevier Science Ltd. All rights reserved.

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收藏

页码：1635 / 1638

页数：4

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