The potential role of vascular endothelial growth factor (VEGF) in cartilage - How the angiogenic factor could be involved in the pathogenesis of osteoarthritis?

被引：146

作者：

Murata, M. ^{[1
]}

Yudoh, K. ^{[1
]}

Masuko, K. ^{[1
]}

机构：

[1] St Marianna Univ, Sch Med, Dept Bioregulat & Proteom, Kawasaki, Kanagawa 2168511, Japan

来源：

OSTEOARTHRITIS AND CARTILAGE | 2008年 / 16卷 / 03期

关键词：

vascular endothelial growth factor; chondrocyte; cartilage; hypoxia; osteoarthritis;

D O I：

10.1016/j.joca.2007.09.003

中图分类号：

R826.8 [整形外科学]; R782.2 [口腔颌面部整形外科学]; R726.2 [小儿整形外科学]; R62 [整形外科学（修复外科学）];

学科分类号：

摘要：

Although adult human cartilage is physiologically avascular tissue, angiogenesis can be observed during the process of endochondral bone development. Inflammation in articular joints can also lead to neovascularization in cartilage. In such conditions, the expression of angiogenic factors, such as vascular endothelial growth factor (VEGF), has been shown to play a key role, controlling not only angiogenesis but also chondrocyte metabolism. Here we review recent research findings concerning the potential role of VEGF in cartilage, focusing in particular on its possible involvement in the pathogenesis of osteoarthritis. (C) 2007 Osteoarthritis Research Society International. Published by Elsevier Ltd. All rights reserved.

引用

页码：279 / 286

页数：8

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