Synthesis and structure-activity relationships of a series of novel thiazoles as inhibitors of aminoacyl-tRNA synthetases

被引：31

作者：

Yu, XY

Hill, JM

Yu, GX

Wang, WH

Kluge, AF

Wendler, P

Gallant, P

机构：

[1] Cubist Pharmaceut Inc, Dept Med Chem, Cambridge, MA 02139 USA

[2] Cubist Pharmaceut Inc, Dept Biol, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1999年 / 9卷 / 03期

关键词：

D O I：

10.1016/S0960-894X(98)00738-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel aminoacyl adenylate mimics has been prepared and evaluated for their inhibitory activity against aminoacyl-tRNA synthetases. Several of these thiazole derivatives displayed potent and selective enzyme activity against both Gram-positive and Gram-negative bacteria. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

收藏

页码：375 / 380

页数：6

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