Ontogenetic development of Loxosceles intermedia spider venom

被引：33

作者：

de Andrade, RMG ^{[1
]}

De Oliveira, KC ^{[1
]}

Giusti, AL ^{[1
]}

da Silva, WD ^{[1
]}

Tambourgi, DV ^{[1
]}

机构：

[1] Butantan Inst, Lab Immunochem, BR-05503900 Sao Paulo, Brazil

来源：

TOXICON | 1999年 / 37卷 / 04期

基金：

巴西圣保罗研究基金会;

关键词：

D O I：

10.1016/S0041-0101(98)00200-1

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Envenomation by Loxosceles spider has become a public health problem in the South region of Brazil, mainly due to high levels of domiciliary infestation by Loxosceles intermedia spiders. The toxic effects of L. intermedia venom are mostly associated with a 35 kDa protein (F35) which presents complement-dependent haemolytic and dermonecrotic activities. The aim of this study was to detect, through biological and immunochemical assays, the appearance of the main toxic component, F35, during the ontogenetic development of L. intermedia spiders. The toxin appeared in its fully active form in venom of third instar spiderlings; from then on its activity increased throughout development until adulthood. On the other hand, F35 was not detected in extracts of either eggs or spiderlings of the first and second instars. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：627 / 632

页数：6

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