ClpP: A distinctive family of cylindrical energy-dependent serine proteases

被引:178
作者
Yu, Angela Yeou Hsiung [1 ]
Houry, Walid A. [1 ]
机构
[1] Univ Toronto, Dept Biochem, Toronto, ON M5S 1A8, Canada
关键词
C1pP; cylindrical protease; serine protease; C1pR; AAA plus chaperone;
D O I
10.1016/j.febslet.2007.04.076
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
Processes maintaining protein homeostasis in the cell are governed by the activities of molecular chaperones that mainly assist in the folding of polypeptide chains and by a large class of proteases that regulate protein levels through degradation. ClpP proteases; define a distinctive family of cylindrical, energy-dependent serine proteases that are highly conserved throughout bacteria and eukaryota. They typically interact with ATP-dependent AAA+ chaperones; that bind and unfold target substrates and then translocate them into ClpP for degradation. Structural and functional studies have provided a detailed view of the mechanism of function of this class of proteases. (c) 2007 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
引用
收藏
页码:3749 / 3757
页数:9
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