Design of emission ratiometric metal-ion sensors with enhanced two-photon cross section and brightness

被引：111

作者：

Sumalekshmy, S.

Henary, Maged M.

Siegel, Nisan

Lawson, PaDreyia V.

Wu, Yonggang

Schmidt, Karin

Bredas, Jean-Luc

Perry, Joseph W.

Fahrni, Christoph J.

机构：

[1] Georgia Inst Technol, Sch Chem & Biochem, Petit Inst Bioengn & Biosci, Atlanta, GA 30332 USA

[2] Georgia Inst Technol, Ctr Organ Photon & Elect, Atlanta, GA 30332 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 39期

关键词：

D O I：

10.1021/ja073240o

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

To develop metal-responsive fluorescence probes with optimized nonlinear optical properties for two-photon excitation fluorescence microscopy (TPEM), we investigated the utility of donor-acceptor architectures where the metal-ion coordinates to the acceptor rather than donor site of the fluorophore. Zn(II) binding to such a probe consisting of a tris(picolyl)amine-substituted acceptor site connected with an anisole donor moiety and an oxazole central core resulted in a significant increase of the two-photon absorption cross section (delta) and fluorescence brightness (eta delta). The fluorophore showed also a strong shift of the emission peak upon saturation with Zn(II), rendering the proposed approach suitable for two-photon excited emission ratiometric sensing.

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收藏

页码：11888 / +

页数：3

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