Synthesis and biological screening of 7-hydroxy-4-methyl-2H-chromen-2-one, 7-hydroxy-4,5-dimethyl-2H-chromen-2-one and their some derivatives

被引：18

作者：

Khan, KM ^{[1
]}

Saify, ZS

Begum, S

Noor, F

Khan, MZ

Hayat, S

Choudhary, MI

Perveen, S

Atta-Ur-Rahman

Zia-Ullah

机构：

[1] Univ Karachi, HEJ Res Inst Chem, Int Ctr Chem Sci, Karachi 75270, Pakistan

[2] Univ Karachi, Fac Pharm, Karachi 75270, Pakistan

[3] Univ Karachi, Dept Chem, Karachi 75270, Pakistan

[4] PCSIR Labs Complex, Karachi 75280, Pakistan

来源：

NATURAL PRODUCT RESEARCH | 2003年 / 17卷 / 02期

关键词：

7-hydroxy-4-methyl-2H-chromen-2-one; 7-hydroxy-4,5-dimethyl-2H-chromen-2-one derivatives; cytotoxicity; bactericidal activity;

D O I：

10.1080/1478641031000103704

中图分类号：

O69 [应用化学];

学科分类号：

081704 [应用化学];

摘要：

7-Hydroxy-4-methyl-2H-chromen-2-one (2), 7-hydroxy-4,5-dimethyl-2H-chromen-2-one (15) and their some derivatives were synthesized for exploring selected biological screening. The compounds 9 and 13 had shown high degree of cytotoxic activity. Three compound 9, 10 and 13 showed high degree of bactericidal activity amongst the present series.

引用

页码：115 / 125

页数：11

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