Tandem cationic aza-Cope rearrangement-Mannich cyclization approach to the core structure of FR901483 via a bridgehead iminium ion

被引：49

作者：

Brummond, KM ^{[1
]}

Lu, JL ^{[1
]}

机构：

[1] W Virginia Univ, Dept Chem, Morgantown, WV 26506 USA

来源：

ORGANIC LETTERS | 2001年 / 3卷 / 09期

关键词：

D O I：

10.1021/ol010029n

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

[GRAPHICS] An approach to the potent immunosuppressant FR901483 is described, This route utilizes a tandem cationic aza-Cope rearrangement-Mannich cyclization to generate the core structure of this compound. In addition, this is the first demonstration of this tandem reaction passing through a bridgehead iminium ion.

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页码：1347 / 1349

页数：3

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