Two novel oleanolic acid saponins having a sialyl Lewis X mimetic structure from Achyranthes fauriei root

被引：37

作者：

Ida, Y ^{[1
]}

Satoh, Y ^{[1
]}

Katsumata, M ^{[1
]}

Nagasao, M ^{[1
]}

Hirai, Y ^{[1
]}

Kajimoto, T ^{[1
]}

Katada, N ^{[1
]}

Yasuda, M ^{[1
]}

Yamamoto, T ^{[1
]}

机构：

[1] Showa Univ, Sch Pharmaceut Sci, Tokyo 1428555, Japan

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(98)00457-0

中图分类号：

R914 [药物化学];

学科分类号：

100701 [药物化学];

摘要：

Two novel triterpene glycosides, achyranthosides E and F, were isolated as methyl eaters from the root of Achyranthes fauriei, an antiinflammatory medicinal plant. Their structures were characterized as oleanolic acid glucuronides having unique substituents composed of C6H9O5 and C9H15O7, respectively, at the C-3 position of glucuronic acid. These compounds are active components which can inhibit the excess recruiting of neutrophiles to injured tissues 1,000 times more potently than sialyl Lewis X. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：2555 / 2558

页数：4

共 9 条

[1]

ARITOMI M, 1970, CHEM PHARM BULL, V18, P677

[2]

IDA Y, 1995, CHEM PHARM BULL, V43, P896

[3]

ACHYRANTHOSIDE-A AND ACHYRANTHOSIDE-B, NOVEL CYTOTOXIC SAPONINS FROM ACHYRANTHES-FAURIEI ROOT [J].