Peroxynitrite oxidises catechols to o-quinones

被引：58

作者：

Kerry, N

Rice-Evans, C

机构：

[1] St Thomas Sch Biomed Sci, London SE1 9RT, England

[2] Kings Coll London, Antioxidant Res Ctr, London SE1 9RT, England

来源：

FEBS LETTERS | 1998年 / 437卷 / 03期

关键词：

caffeic acid; oxidation; antioxidant; o-quinone; peroxynitrite; glutathione;

D O I：

10.1016/S0014-5793(98)01223-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Nitration of phenolic compounds is a well-established mechanism on interaction with peroxynitrite. However, while nitration is the predominant reaction for monophenolic hydroxycinnamates, this does not take place with the catechol-containing hydroxycinnamate, caffeic acid. The aim of the present study was to investigate the mechanism of the chemical interaction of caffeic acid with peroxynitrite and to characterise the products formed. A novel compound was detected and characterised as the o-quinone of caffeic acid based on its reaction with nucleophilic thiol compounds, glutathione and L-cysteine, The same novel product was identified following the oxidation of caffeic acid in alkaline solutions confirming the identity of this species as a caffeic acid oxidation product. (C) 1998 Federation of European Biochemical Societies.

引用

页码：167 / 171

页数：5

共 18 条

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[2]

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