Nucleoside transport and its significance for anticancer drug resistance

被引：132

作者：

Mackey, JR

Baldwin, SA

Young, JD

Cass, CE

机构：

[1] Univ Alberta, Dept Oncol, Edmonton, AB T6G 1Z2, Canada

[2] Cross Canc Inst, Edmonton, AB T6G 1Z2, Canada

[3] Univ Leeds, Sch Biochem & Mol Biol, Leeds LS2 9JT, W Yorkshire, England

[4] Univ Alberta, Dept Physiol, Edmonton, AB T6G 1Z2, Canada

来源：

DRUG RESISTANCE UPDATES | 1998年 / 1卷 / 05期

基金：

英国医学研究理事会; 英国惠康基金;

关键词：

D O I：

10.1016/S1368-7646(98)80047-2

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

This article discusses the role of nucleoside transport processes in the cytotoxicity of clinically important anticancer nucleosides. This article summarizes recent advances in the molecular biology of nucleoside transport proteins, review the current state of knowledge of the transportability of therapeutically useful anticancer nucleosides, and provide an overview of the role of nucleoside transport deficiency as a mechanism of resistance to nucleoside cytotoxicity are summarized. Several strategies for utilization of nucleoside transport processes to improve the therapeutic index of anticancer therapies, including the use of nucleoside-transport inhibitors to modulate toxicity of both nucleoside and nonnucleoside antimetabolite drugs are also presented.

引用

页码：310 / 324

页数：15

共 128 条

[1] PROTECTION AGAINST FLUDARABINE NEUROTOXICITY IN LEUKEMIC MICE BY THE NUCLEOSIDE TRANSPORT INHIBITOR NITROBENZYLTHIOINOSINE [J].